Vaccine development vaccine development evaluation of clinical samples Western blots ELISA FACS cell based bacteriocidal activity in vivo assays




            

M.S. in Biology   RENSSELAER Polytechnic INSTITUTE   1980

 
 

B.S. in Biology   RENSSELAER Polytechnic INSTITUTE    1979

 
 

Hedy Adari, Ph.D.                    Page 4

 
 
 
 

ADDITIONAL TRAINING

 
 

Project Management in Biotechnology (MBC sponsored course)     2007

BIAcore training (by Biacore Life Sciences)          1996

 
 
 
 
 

AWARDS AND HONORS

 
 

T Cell Sciences, Inc. Scientific Achievement Award        1994

T Cell Sciences, Inc. Scientific Achievement Award        1997

 
 
 
 
 

INVITED PRESENTATION

 
 

Adari, H., Frazer, K., Karalius, B., Chhung, Y., and K.  Killeen, ‘Development of an oral, live-attenuated V. cholerae-vectored Shigella sonnei bivalent vaccine candidate against cholera and Shigellosis’, Vaccines for Enteric Diseases Conference, Lisbon, Portugal, April 2007.

 
 
 
 
 

PATENTS

 
 

Adari H., Thomas L., Rittershaus C.W. (2006) Modulation of Cholesteryl ester transfer protein (CETP) activity. US application #: 20060276400

 
 

Adari H., Thomas L., Rittershaus C.W. (2006) Modulation of Cholesteryl ester transfer protein (CETP) activity. European application #: WO2006133196

 
 
 

Hedy Adari, Ph.D.                    Page 5

 
 
 

PUBLICATIONS

 
 
 

  1. Thomas, L.J.,  Picard, M.D., Miller, D.P., Adari, H., Beattie, D.T., Emmett, C.D., Rittershaus, C.W., Pettey, C.L. (2003) Modifications of the Cholesterol-Fed Rabbit Model of Atherosclerosis Using Diets with Different Levels of Cholesterol Supplementation. Preclinica May/June: 15-25.

 
 

  1. Rittershaus, C.W., Miller, D.P., Thomas, L.J., Picard, M.D., Honan, C.M., Emmett, C.D., Pettey, C.L., Adari, H., Hammond, D.T. Beattie, R.A., Callow, A.D., Marsh, H.C., Ryan, U.S. (2000) Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis. Atheroscler. Thromb. Vasc. Biol. 20: 2106-2112.

 
 

  1. Rittershaus, C.W., Thomas, L.J., Miller, D.P., Picard, M.D., Geoghegan-Barek, K.M., Scesney, S.M., Henry, L.D., Sen, A.C., Bertino, A.M., Hannig, G., Adari, H.Y., Mealey, R.A., Gosselin, M.L., Couto, A., Hayman, E.G., Levin, J.L., Reinhold, V.N. and Marsh, H.C.(1999) Recombinant Glycoproteins Which Inhibit Complement and also Bind the Selectin Adhesion Molecules. J. Biol. Chem. 274:11237-11244.

 
 

  1. Herrera, V.M., Makrides, S.C., Xie, H.X., Adari, H., Ryan U., Ruiz-Opazo, N. (1999) Spontaneous combined hyperlipidemia, coronary heart disease and decreased survival in Dahl salt-sensitive hypertensive rats transgenic for human cholesteryl ester transfer protein. Nat. Med. 5:1383-1389.

 
 

  1. Andrews, B., Adari, H. Y., Hannig, G., Lahue, E., Gosselin, M., Martin, S., Ahmed, A., Ford, P., Hayman, E. G., and S. Makrides (1996) A tightly regulated high level expression vector that utilizes a thermosensitive lac repressor: production of the human T cell receptor Vb5.3 in Escherichia coli Gene. 182: 101-109.

 
 

  1. Makrides, S., Nygren, P.-A. Andrews, B., Ford, P., Evans, K., Hayman, E. G.,  Adari, H.Y. Levin, J., Uhlen, M.,  and C. Toth. (1996) Extended in vivo half-life of human soluble complement receptor type 1 fused to a serum-albumin binding receptor. J. Pharm. Exp. Ther. 277: 534-542.

 
 

  1. Adari, H. Y., Andrews, B., Ford, P., Hannig, G., Brosius, J., and S. Makrides. (1995) Expression of the human T-cell receptor Vb5.3 in Escherichia coli by thermal induction of the trc promotor: nucleotide sequence of the LacIts gene. Biochim. Biophys. Acta. 14: 945-950.

 
 

  1. Webster, K.R., Adari, H.Y. and E.K. Spicer (1989) Bacteriophage T4 reg A protein binds to the Shine-Delgarno sequence of gene 44 mRNA. Nucleic Acid Res. 17: 10047-10068.

 
 

  1. McCormick, F., Adari, H., Trahey, M., Halenbeck, R., Kowths, K., Martin, G.A., Crosier, W.J., Watt,K., Rubinfeld, B. and G. Wong (1988) Interaction of ras p21 proteins with GTP activating protein. CSHSQB 53: 849-854.

 
 

  1. Adari, H., Lowy, D.R., Willumsen, B.M., Der, C.J., and F. McCormick (1988) Guanosine triphosphate activator protein (GAP) interacts with the p21 ras effector binding domain. Science 240:518-521.

Hedy Adari, Ph.D.                    Page 6

 
 
 

  1. Adari, H. T4 Bacteriophage RegA Protein: Cloning, Purification and Functional Studies of a Translational Repressor. (Doctoral Thesis) Yale University, New Haven, CT, 1987.

 
 

  1. Wilson D, Adari H. (1987) The genes for galactokinase and uridine monophosphatase-2 are syntenic in the dog (Canis familiaris). Biochem. Genet. 25: 815-819.

 
 

  1. Adari, H. and E.K. Spicer (1986) Translational repression in vitro by the bacteriophage T4 reg A protein. Proteins 1: 116-124.

 
 

  1. Shamoo, Y., Adari, H., Konigsberg, W.H., Williams, K.R. and J. Chase (1986) Cloning of T4 gene 32 and expression of the wild type under PL regulation in E. coli. Proc Natl. Acad. Sci. USA  83: 8844-8848.

 
 

  1. Adari, H., Rose, K., Williams, K.R., Konigsberg, W.H., Lin, T-C. and   E.K. Spicer (1985) Cloning, nucleotide sequence and overexpression of the bacteriophage T4 reg A gene. Proc. Natl. Acad. Sci. USA 82:1901-1905.

 
 

  1. Adari, H. (1980) Identified syngeneic groups of genes in mammalian evolution. (Master Thesis) Rensselaer Polytechnic Institute, Troy, NY.

 
 

  1. Roy, H., Adari, H., and K.A. Costa (1979) Characterization of free subunits of ribulose 1,5 bisphosphate carboxylase. Plant Sci. L. 16: 305- 318.

 
 

  1. Roy, H. Costa, K.A. and H. Adari (1978) Free subunits of ribulose 1,5-bisphosphate carboxylase in pea leaves. Plant Sci. L. 11: 159-165.
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    Vaccine development vaccine development evaluation of clinical samples Western blots ELISA FACS cell based bacteriocidal activity in vivo assays

                

    M.S. in Biology   RENSSELAER Polytechnic INSTITUTE   1980

     
     

    B.S. in Biology   RENSSELAER Polytechnic INSTITUTE    1979

     
     

    Hedy Adari, Ph.D.                    Page 4

     
     
     
     

    ADDITIONAL TRAINING

     
     

    Project Management in Biotechnology (MBC sponsored course)     2007

    BIAcore training (by Biacore Life Sciences)          1996

     
     
     
     
     

    AWARDS AND HONORS

     
     

    T Cell Sciences, Inc. Scientific Achievement Award        1994

    T Cell Sciences, Inc. Scientific Achievement Award        1997

     
     
     
     
     

    INVITED PRESENTATION

     
     

    Adari, H., Frazer, K., Karalius, B., Chhung, Y., and K.  Killeen, ‘Development of an oral, live-attenuated V. cholerae-vectored Shigella sonnei bivalent vaccine candidate against cholera and Shigellosis’, Vaccines for Enteric Diseases Conference, Lisbon, Portugal, April 2007.

     
     
     
     
     

    PATENTS

     
     

    Adari H., Thomas L., Rittershaus C.W. (2006) Modulation of Cholesteryl ester transfer protein (CETP) activity. US application #: 20060276400

     
     

    Adari H., Thomas L., Rittershaus C.W. (2006) Modulation of Cholesteryl ester transfer protein (CETP) activity. European application #: WO2006133196

     
     
     

    Hedy Adari, Ph.D.                    Page 5

     
     
     

    PUBLICATIONS

     
     
     

    1. Thomas, L.J.,  Picard, M.D., Miller, D.P., Adari, H., Beattie, D.T., Emmett, C.D., Rittershaus, C.W., Pettey, C.L. (2003) Modifications of the Cholesterol-Fed Rabbit Model of Atherosclerosis Using Diets with Different Levels of Cholesterol Supplementation. Preclinica May/June: 15-25.

     
     

    1. Rittershaus, C.W., Miller, D.P., Thomas, L.J., Picard, M.D., Honan, C.M., Emmett, C.D., Pettey, C.L., Adari, H., Hammond, D.T. Beattie, R.A., Callow, A.D., Marsh, H.C., Ryan, U.S. (2000) Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis. Atheroscler. Thromb. Vasc. Biol. 20: 2106-2112.

     
     

    1. Rittershaus, C.W., Thomas, L.J., Miller, D.P., Picard, M.D., Geoghegan-Barek, K.M., Scesney, S.M., Henry, L.D., Sen, A.C., Bertino, A.M., Hannig, G., Adari, H.Y., Mealey, R.A., Gosselin, M.L., Couto, A., Hayman, E.G., Levin, J.L., Reinhold, V.N. and Marsh, H.C.(1999) Recombinant Glycoproteins Which Inhibit Complement and also Bind the Selectin Adhesion Molecules. J. Biol. Chem. 274:11237-11244.

     
     

    1. Herrera, V.M., Makrides, S.C., Xie, H.X., Adari, H., Ryan U., Ruiz-Opazo, N. (1999) Spontaneous combined hyperlipidemia, coronary heart disease and decreased survival in Dahl salt-sensitive hypertensive rats transgenic for human cholesteryl ester transfer protein. Nat. Med. 5:1383-1389.

     
     

    1. Andrews, B., Adari, H. Y., Hannig, G., Lahue, E., Gosselin, M., Martin, S., Ahmed, A., Ford, P., Hayman, E. G., and S. Makrides (1996) A tightly regulated high level expression vector that utilizes a thermosensitive lac repressor: production of the human T cell receptor Vb5.3 in Escherichia coli Gene. 182: 101-109.

     
     

    1. Makrides, S., Nygren, P.-A. Andrews, B., Ford, P., Evans, K., Hayman, E. G.,  Adari, H.Y. Levin, J., Uhlen, M.,  and C. Toth. (1996) Extended in vivo half-life of human soluble complement receptor type 1 fused to a serum-albumin binding receptor. J. Pharm. Exp. Ther. 277: 534-542.

     
     

    1. Adari, H. Y., Andrews, B., Ford, P., Hannig, G., Brosius, J., and S. Makrides. (1995) Expression of the human T-cell receptor Vb5.3 in Escherichia coli by thermal induction of the trc promotor: nucleotide sequence of the LacIts gene. Biochim. Biophys. Acta. 14: 945-950.

     
     

    1. Webster, K.R., Adari, H.Y. and E.K. Spicer (1989) Bacteriophage T4 reg A protein binds to the Shine-Delgarno sequence of gene 44 mRNA. Nucleic Acid Res. 17: 10047-10068.

     
     

    1. McCormick, F., Adari, H., Trahey, M., Halenbeck, R., Kowths, K., Martin, G.A., Crosier, W.J., Watt,K., Rubinfeld, B. and G. Wong (1988) Interaction of ras p21 proteins with GTP activating protein. CSHSQB 53: 849-854.

     
     

    1. Adari, H., Lowy, D.R., Willumsen, B.M., Der, C.J., and F. McCormick (1988) Guanosine triphosphate activator protein (GAP) interacts with the p21 ras effector binding domain. Science 240:518-521.

    Hedy Adari, Ph.D.                    Page 6

     
     
     

    1. Adari, H. T4 Bacteriophage RegA Protein: Cloning, Purification and Functional Studies of a Translational Repressor. (Doctoral Thesis) Yale University, New Haven, CT, 1987.

     
     

    1. Wilson D, Adari H. (1987) The genes for galactokinase and uridine monophosphatase-2 are syntenic in the dog (Canis familiaris). Biochem. Genet. 25: 815-819.

     
     

    1. Adari, H. and E.K. Spicer (1986) Translational repression in vitro by the bacteriophage T4 reg A protein. Proteins 1: 116-124.

     
     

    1. Shamoo, Y., Adari, H., Konigsberg, W.H., Williams, K.R. and J. Chase (1986) Cloning of T4 gene 32 and expression of the wild type under PL regulation in E. coli. Proc Natl. Acad. Sci. USA  83: 8844-8848.

     
     

    1. Adari, H., Rose, K., Williams, K.R., Konigsberg, W.H., Lin, T-C. and   E.K. Spicer (1985) Cloning, nucleotide sequence and overexpression of the bacteriophage T4 reg A gene. Proc. Natl. Acad. Sci. USA 82:1901-1905.

     
     

    1. Adari, H. (1980) Identified syngeneic groups of genes in mammalian evolution. (Master Thesis) Rensselaer Polytechnic Institute, Troy, NY.

     
     

    1. Roy, H., Adari, H., and K.A. Costa (1979) Characterization of free subunits of ribulose 1,5 bisphosphate carboxylase. Plant Sci. L. 16: 305- 318.

     
     

    1. Roy, H. Costa, K.A. and H. Adari (1978) Free subunits of ribulose 1,5-bisphosphate carboxylase in pea leaves. Plant Sci. L. 11: 159-165.
    PrePage123
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