Principal Investigator/Program Director (Last, First, Middle): 

1. Positions and Honors.

PROFESSIONAL EXPERIENCE

1979-1982  Resident in Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY

1981-1984  NIMH Funded Research Fellowship, Department of Psychiatry, Columbia University, New York, NY

1984-1989  Assistant Professor of Psychiatry, Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA

1989-1995  Associate Professor of Psychiatry, Department of Psychiatry, University of Pittsburgh School of Medicine,  
     Western Psychiatric Institute and Clinic, Pittsburgh, PA

1995-Present Professor of Psychiatry, Department of Psychiatry, University of Pittsburgh School of Medicine, Western  
     Psychiatric Institute and Clinic, Pittsburgh, PA 
 

CERTIFICATION

1983    General Psychiatry, American Board of Psychiatry and Neurology

1987    Child Psychiatry, American Board of Psychiatry and Neurology 
 

HONORS

1994    Gerald L. Klerman Young Investigator Award

1995   Joaquim Puig-Antich Professor in Child and Adolescent Psychiatry 
 

2. Selected peer-reviewed publications (in chronological order).

SELECTED PUBLICATIONS - Author of more than 100 publications; the following are listed for this proposal:

Ryan ND, Meyer VA, Dachille S, Mazzie D, Puig-Antich J:  Lithium antidepressant augmentation of TCA-refractory Depression in adolescents.  Journal Am Acad Child and Adol Psychiatry, 27:371-376, 1988.

Ryan N, Puig-Antich J, Rabinovich H, Fried J, Ambrosini P, Meyer V, Torres D, Dachille S, Mazzie D:  MAOIs in adolescent major Depression unresponsive to tricyclic antidepressants.  Journal Am Acad Child and Adol Psychiatry, 27:755-758, 1988.

Ryan ND, Puig-Antich J, Rabinovich H, Ambrosini P, Robinson D, Nelson B, Novacenko H:  Growth hormone response to desmethylimipramine in depressed and suicidal adolescents.  Journal of Affective Disorders, 15:323-337, 1988.

Ryan ND:  Major Depression.  Handbook of Child Psychiatric Diagnosis, CG Last and M Hersen (eds), John Wiley and Sons, New York, 1988.

Dahl R, Puig-Antich J, Ryan N, Nelson B, Novacenko H, Twomey J, Williamson D, Goetz R, Ambrosini P:  Cortisol secretion in adolescents with major depressive disorder.  Acta Psychiatrica Scandinavia, 80:18-26, 1989.

Dahl R, Puig-Antich J, Ryan ND, Nelson B, Dachille S, Cunningham S, Trubnick L, Klepper T:  EEG sleep in adolescents with major depressive disorder:  The role of suicidality and inpatient status.  Journal Affective Disorders, 19:63-75, 1990.

Ryan ND:  Heterocyclic antidepressants in children and adolescents.  Journal of Child and Adol Psychopharmacology, 1:21-31, 1990.

Ryan ND:  Pharmacotherapy of adolescent major Depression:  Beyond TCAs.  Psychopharmacology Bulletin, 26:75-79, 1990.

Ryan ND, Williamson DE, Iyengar S, Orvaschel H, Reich T, Dahl RE, Puig-Antich JA:  A secular increase in child and adolescent onset affective disorder.  Journal of Am Acad Child and Adol Psychiatry, 31:600-605, 1992.

Ryan ND, Birmaher B, Perel JM, Dahl RE, Meyer V, Al-Shabbout M, Iyengar S, Puig-Antich J:  Neuroendocrine response to L-5-hydroxytrptophan challenge in prepubertal major Depression:  Depressed versus normal children.  Arch Gen Psychiatry, 49:843-851, 1992.

Puig-Antich J, Kaufman J, Ryan ND, Williamson DE, Dahl RE, Lukens E, Todak G, Ambrosini P, Rabinovich H, Nelson B:  The psychosocial functioning and family environment of depressed adolescents.  J Am Acad Child and Adol Psychiatry, 32:244-253, 1993.

Ryan ND and Dahl RE:  The Biology of Depression in Children and Adolescents.  The Biology of Depressive Disorders, JJ Mann and DJ Kupfer (eds), Plenum Press, New York, 1993.

Ryan ND, Dahl RE, Birmaher B, Williamson DE, Iyengar S, Nelson B, Puig-Antich J, Perel JM:  Stimulatory tests of growth hormone secretion in prepubertal major Depression:  Depressed versus normal children.  J Am Acad Child and Adol Psychiatry, 33:824-833, 1994.

Williamson DE, Birmaher B, Anderson BP, Al-Shabbout M, Ryan ND:  Stressful life events in depressed adolescents:  The role of dependent events during the depressive episode.  Journal of the Am Acad of Child and Adol Psychiatry, 34:591-598, 1995.

Birmaher B, Ryan ND, Brent DA, Williamson DE, Kaufman J, Dahl RE, Perel J, Nelson B: Childhood and adolescent Depression: A  review of the past ten years, Part I.  Journal  Am Acad of Child and Adol Psychiatry, 35(11):1427-1439, 1996.

Ryan ND, Varma D: Child and adolescent mood disorders--experience with 5-HT based therapies.  Conference on Amelia Island, FL, AA Decade of Serotonin Research@, Biological Psychiatry, 44:336-340, 1998.

Ryan ND, Bhatara VS, Perel JM: Mood stabilizers in children and adolescents.  J Am Acad of Child and Adol Psychiatry, 38:529-536, 1998.

Weissman MM, Wolk S, Wickramaratne P, Goldstein RB, Adams P, Greenwald S, Ryan ND, Dahl RE, Steinberg D: Children with prepubertal-onset major depressive disorder and anxiety grown up.  Archives of General Psychiatry, 56:794-801, 1999.

Ryan ND: Pharmacologic and psychotherapeutic treatments for adolescent Depression.  The Economics of Neuroscience (TEN),  7:49-51, 2000.

De Bellis MD, Casey BJ, Dahl R, Birmaher B, Williamson D, Thomas KM, Axelson DA, Frustaci K, Boring AM, Hall J, Ryan ND.  A pilot study of amygdala volumes in pediatric generalized anxiety disorder.  Biological Psychiatry,  48:51-57, 2000.

Dahl RE, Birmaher B, Williamson DE, Dorn L, Perel J, Kaufman J, Brent DA, Axelson DA, Ryan ND:  Low growth hormone response to growth hormone-releasing hormone in child Depression.  Biological Psychiatry,  48:981-988, 2000.

Thomas KM, Drevets W, Whalen PJ, Eccard CH, Dahl RE, Ryan ND,  Eccard CH,  Casey BJ:  Amygdala response to facial expressions in children and adults.  Biological Psychiatry,  49:309-316, 2001.

Ryan ND:  Diagnosing Pediatric Depression.  Biological Psychiatry,  49:1050-1054, 2001.

Thomas KM, Drevets WC, Dahl RE, Ryan ND, Birmaher B, Eccard CH, Axelson D, Whalen PJ, Casey BJ:  Amygdala response to fearful faces in anxious and depressed children.  Archives of General Psychiatry,  58:1057-1063, 2001.

Keller MB, Ryan ND, Strober M, Klein RG, Kutcher S, Birmaher B, Hagino OR, Koplewicz H, Carlson GA, Clarke G, Emslie GH, Feinberg D, Geller B, Kusumakar V, Papatheodorou G, Sack WH, Sweeney M, Wagner KD, Weller EB, Winters NC, Oakes R, McCafferty JP:  Efficacy of paroxetine in the treatment of adolescent major Depression:  A randomized, controlled trial.  Journal of the American Academy of Child and Adolescent Psychiatry. July 40:762-72    

2001.

Charney DS, Nemeroff CB, Lewis L, Laden SK, Gorman JM, Ryan ND etal:  National Depressive and Manic-Depressive Association Consensus Statement on the Use of Placebo in Clinical Trials of Mood Disorders. Archives of General Psychiatry.  59: 262-270, 2002. 

Rao, Uma; Dahl, Ronald E; Ryan, Neal D; Birmaher, Boris; Williamson, Douglas E; Rao, Radhika; Kaufman, Joan: Heterogeneity in EEG sleep findings in adolescent Depression: Unipolar versus bipolar clinical course. Journal of Affective Disorders. 70(3): 273-280, 2002.

Stein D, Williamson DE, Birmaher B, Brent DA, Kaufman J, Dahl RE, Ryan ND: Parent-child bonding and family functioning in depressed children, and children at high-risk and low-risk for future Depression. Yearbook of Psychiatry & Applied Mental Health. 2002:14-16, 2002.

Williamson, Douglas E; Coleman, Kris; Bacanu, Silviu-Alin; Devlin, Bernie J; Rogers, Jeffrey; Ryan, Neal D; Cameron, Judy L.: Heritability of fearful-anxious endophenotypes in infant rhesus macaques: A preliminary report.  Biological Psychiatry. 53(4): 284-291, 2003.

Ryan, Neal D:  Medication treatment for Depression in children and adolescents. CNS Spectrums. 6(4): 283 – 287, 2003. 
 

C. Research Support.

Ongoing Research Support 
 

      5 G08 LM06625-05  Friedman (PI)         5/1/98 - 4/30/03    

      NLM  
 

IAIMS Implementation: Advancing the Academic Mission Implement and sustain a management structure that promotes progress toward our Integrated Advanced Information Management  
Systems (IAIMS) vision. Design and implement an enterprise integrated systems architecture.

      Role: Co-Investigator  
 

     1 R01 MH 64851-01A1 Axelson (PI)         9/24/02 - 8/30/04  

      NIMH

      Treatment of Early Age Mania

      To investigate the effectiveness of medications for children and adolescents who have BP-1 (manic or mixed-phase)

      or mania.  To pilot a complex, multistrata, adaptive strategy design.

      Role: Co-Investigator – 10% 
 

      1 R01 AA12504-03  Dahl (PI)          5/1/00 - 4/30/05  

      NIAAA 

      Sleep/Arousal in Adolescence: Pathways to Alcohol Abuse

      The primary goal of this program of research is to examine measures of sleep/arousal and affect regulation in

       relation to developmental trajectories across adolescence leading to alcohol abuse/dependence.

       Role: Co-Principal Investigator 
 

      1 R01 MH61596-02  Dahl (PI)          7/1/01 - 6/30/05    

      NIMH 

      Neuroimaging Markers of Vulnerability to Depression

      To test hypotheses about the neurobiological basis of MDD, the systems implicated by these studies will be

      examined in a unique and informative sample of young adults.

       Role:  Co-Investigator     
 

      5 R01 MH59929-02 Birmaher (PI)                8/1/00 - 7/30/05 

      NIMH 

      Course and Outcome for Adolescents with Bipolar Illness

      Test hypotheses that protracted course of recovery and increased hazard of relapse will be associated with mixed

      states, psychosis, exposure to negative life events, family conflict, and co-morbid substance use disorders.

      Role: Co-Principal Investigator