suppresses nonmetastatic colon cancer at an early stage of tumorigenesis. Cancer Res

 
The research goals of the laboratory are to determine the functions of the Transforming Growth Factors beta (TGFb ) and the Fibroblast Growth Factor-2 (FGF2). Knockout mice for these genes have become important models for reproductive disorders, autoimmune disease, platelet dysfunction and colon cancer (Tgfb1), congenital defects of the heart, skeleton, eye, ear and urogenital tract (Tgfb2) and secondary palate (Tgfb3), low blood pressure (Fgf2), and resistance to cardiac hypertrophy (Fgf2 and Tgfb1). 
 

时间：11月10日下午3:30－4:30点

地点：法医楼二楼会议室 
 
 
 
 
 
 
 

Thomas Doetschman 教授简介 
 

      Thomas Doetschman 教授是美国ＮＩＨ动物科学顾问委员成员，美国辛辛那提大学动物基因敲除实验室主任。多年来，他从事非自然品系小鼠的遗传学研究。在过去的十年里， Thomas Doetschman 教授领导的研究小组，制造了TGF-beta1等多种基因敲除小鼠，广泛应用于心血管系统疾病、生殖系统疾病、自身免疫性疾病、血小板功能降低、癌症等领域。先后在Nature Genetics 、 Nature Medicine 、Nature 等杂志上发表了论著20余篇。

Selected Publications

1. Bommireddy, R., Ormsby, I., Yin, M., Boivin, G.P., Babcock, G.F., & Doetschman, T. (2003) Transforming Growth Factor Beta1 inhibits Ca2+-calcineurin-mediated activation in thymocytes. J. Immunol., 170:3645-3652.

2. Bommireddy R, Saxena,V., Ormsby,I., Yin,M., Boivin G.P, Babcock GF, Singh,R.R. & Doetschman T. (2003) Transforming growth factor beta-1 regulates lymphocyte homeostasis by preventing activation and subsequent apoptosis of peripheral lymphocytes. J. Immunol., 170:4612-4622.

3. Schultz, J.J., Witt, S.A., Glascock, B.J., Nieman, M.L., Reiser, P.J., Nix, S.L., Kimball, T.R. & Doetschman, T. (2002) TGF-beta1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II. J. Clin Invest, 109:787-796.

4. Sanford, L.P., Kallapur, S., Ormsby, I. & Doetschman, T. (2001) Influence of genetic background on knockout mouse phenotypes. Methods Mol.Biol. 158:217-225.

5. Engle, S.J., Hoying, J.B., Boivin, G.P., Ormsby, I., Gartside, P.S. & Doetschman, T. (1999) Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis. Cancer Res. 59:3379-3386.

6. Hoying, J.B., Yin, M., Diebold, R.J., Ormsby, I., Becker, A. & Doetschman, T. (1999) Transforming Growth Factor-b 1 enhances platelet aggregation through a non-transcriptional effect on the fibrinogen receptor. J. Biol. Chem. 274:31008-31013.

7. Schultz, J.E., Witt, S.A., Nieman, M.L., Reiser, P.J., Engle, S.J., Zhou, M., Pawlowski, S.A., Lorenz, J.N., Kimball, T.R. & Doetschman, T. (1999) Fibroblast growth factor-2 mediates pressure-induced hypertrophic response. J Clin Invest 104:709-719.

8. Zhou, M., Paul, R.J., Sutliff, R.L., Lorenz, J.N., Hoying, J.G., Haudenschild, C.C., Yin, M., Coffin, J.D., Kong, L., Kranias, E.G., Luo, W., Boivin, G.P., Duffy, J.J., Pawlowski, S.A. & Doetschman, T. (1998) FGF2 control of vascular tone. Nature Medicine 4:201-207.

9. Sanford, L.P., Ormsby, I., Gittenberger-de Groot, A.C., Sariola, H., Friedman, R., Boivin, G.P., Cardell, E.L. & Doetschman, T. (1997) TGFb 2 knockout mice have multiple developmental defects that are non overlapping with other TGFb knockout phenotypes. Development 124:2659-2670.

10. Proetzel, G., Pawlowski, S., Yin, M., Boivin, G., Howles, P., Ding, J., Ferguson, M.W.J. & Doetschman, T. (1995) Transforming growth factor-b 3 is required for secondary palate fusion. Nature Genetics 11:409-414.

11. Shull, M.M., Ormsby, I, Kier, A., Pawlowski, S., Diebold, R.J., Yin, M-Y, Allen, R., Sidman, C., Proetzel, G., Calvin, D., Annunziata, N. & Doetschman, T. (1992) Targeted disruption of the murine TGFb 1 gene results in multifocal inflammatory disease. Nature 359:693-699.