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| 鄭光宏 助理 教授 |
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藝術大樓112-1室 |
校內分機 |
5817 |
| 實驗室 |
藝術大樓218室 |
傳真機 |
07-525-0197 |
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| 學 歷 |
1992 高雄醫學院醫技系學士
1995 中興大學分子生物研究所碩士
2003 美國波士頓大學醫學院病理博士 |
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| 經 歷 |
2004-2005 美國波士頓大學附設醫學院博士後研究員
2005-2007 美國哈佛醫學院附設麻州總醫院癌症中心
博士後研究員
2007-2008 美國哈佛醫學院附設柏雷根婦女醫院
博士後研究員 |
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| 研究方向 |
1. Ovarian cancer research
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| 學術榮譽及獎項 |
2008 Ruth L. Kirschstein National Research Service
Award Fellowship (2nd year), USA
2007 Program of Excellence Award, the Ovarian
Cancer Research Fund, Inc., USA
2007 Ruth L. Kirschstein National Research Service
Award Fellowship, USA
2004 10th Russek Student Achievement Awards
(Honorable Mention), Boston University School
of Medicine, USA
2003 Best Poster Award, First Annual Retreat,
Department of Genetics and Genomics, Boston
University School of Medicine, USA
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| 專利 |
- Method of determining gene expression-Targeted Expressed Gene Display- application pending U.S.S.N 60/457,472:BU03-16, Boston University. USA
- A novel loss of heterozygoisity (LOH) analysis method -Dilution End point LOH Analysis (DELA)- application pending, Boston University, USA
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| 學術著作 |
- K.H. Cheng, L. Jebailey, M. Horton and D.M. Dinulescu. (2008) Regulation of ovarian stem-like cancer cells by notch signaling. Manuscript in preparation.
- D.M. Dinulescu, R. Ireton, K.H. Cheng, M. Horton, T. Jacks and S. Hanash. (2008) Discovery and validation of ovarian cancer biomarkers aimed at early detection. Manuscript submitted to Proc Natl Acad Sci U S A.
- Cheng, K.H., A. Hamid, J.F. Ponte, P. Papageorgis and S. Thiagalingam. (2008) The biological and diagnosis importance of Reelin gene expression in cancer. Manuscript submitted to Clin Cancer Res.
- Ponte, J. F., F. Gao, M. Levy, K.H. Cheng, B. Sullivan and S. Thiagalingam. (2008) An hBub1-p53 effector pathway is activated in response to mitotic spindle damage. Manuscript submitted to J. Biol. Chem.
- Bardeesy, N*, Cheng K.H.*, J. H. Berger, G. C. Chu, J. Pahler, P. Olson, J. Horner, G.Y. Lauwers, D. Hanahan and R.A. DePinho. (2006) Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer * equal contribution (first co-authors). Genes & Dev. 20: 3130-3146.
- Abdolmaleky, H., K.H. Cheng, A. Russo, C.L. Smith, S.V. Faraone, R. Shafa, M.Wilcox, S. Glatt, W.S. Stone, G. Nguyen, J.F. Ponte, M. Tsuang and S. Thiagalingam. (2006). Hypomethylation of the COMT gene promoter in brain is elevated in schizophrenia and bipolar disorder. Human Molecular Genetics, 2006 Nov 1;15(21):3132-3145.
- Bardeesy N, Aguirre AJ, Chu GC, Cheng, K.H., Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA. (2006) Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A. Apr 11;103(15): 5947-5952.
- Stanger, B.Z., Stiles, B., Lauwers, G.Y., Bardeesy, N., Mendoza, M., Wang, Y., Greenwood, A., Cheng, K.H., McLaughlin, M., Brown, D., Depinho, R.A., Wu, H, Melton, D.A., and Y. Dor. (2005) Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. Sep; 8(3):185-195.
- Abdolmaleky, H., Cheng, K.H., Russo, A., Smith, C., Faraone, S., Shafa, R., Wilcox, M., Glatt, S., Stone, W., Nguyen, G., Ponte, J.F., Thaigalingam, S., and Tsuang, M. (2005) Hypermethylation of the Reelin (RELN) promoter in the brain of schizophrenic patients: A preliminary report. American J of Medical Genetics. Apr 5;134(1):60-66.
- Pan, H., Califano, J., Ponte, J. F., Russo, A. L., Cheng, K.H., Thiagalingam, A., Liu, G., Spira, A., Sidransky, D., Brody, J.S. and S. Thiagalingam. (2005) LOH patterns provide fingerprints for neoplastic precursor and specific histological subtypes of neoplastic cells of tobacco smoke induced non small cell lung cancer. Cancer Res. Mar 1; 65(5):1664-1669.
- Russo, A. L., Thiagalingam, A., Pan, H., Califano, J., Cheng, K.H., Ponte, J. F, Chinnappan, D., Nemani, P., Sidransky, D and S. Thiagalingam. (2005) Differential DNA hypermethylation status of critical genes identify the stage of tobacco smoke induced neoplastic progression of lung cancer. Clin Cancer Res. 2005 Apr 1;11(7):2466-2470.
- Sam Thiagalingam, Panos Papageorgis and K.H. Cheng. (2004) Is epigenetic inactivation of Smad8 in cancer, a novel tumor maker for diagnosis and therapy? The FASEB Journal 18(8): Suppl. B502.
- Cheng, K.H., J. F. Ponte and S. Thiagalingam. (2004) Elucidation of epigenetic inactivation of SMAD8 in cancer using Targeted Expressed Gene Display. Cancer Res. 64: 1639-1646.
- Thiagalingam, S., K.H. Cheng, H. J. Lee, N. Mineva, and J. F. Ponte. (2003) Histone deacetylases: Unique players in shaping the epigenetic histone code. Annal. New York Acad. Sci. 983: 86-100.
- Kugathasan S, K-h. Cheng, Johnson NA, Ogawa H, Rafiee P, Binion DG, and S. Thiagalingam. (2003) Inactivation of mucosal Smad signaling is associated with the progression from early to late Crohn's disease (CD). Gastroenterology 124 (4): Suppl.A313.
- Thiagalingam, S., K.H. Cheng, R. L. Foy, H. J. Lee, D. Chinnappan, and J. F. Ponte. (2002) TGF beta and its Smad connection to cancer. Current Genomics 3: 449-476.
- Thiagalingam, S., R. L. Foy, K.H. Cheng, H. J. Lee, A. Thiagalingam, and J. F. Ponte. (2002) Loss of heterozygosity (LOH) as a predictor to map tumor suppressor genes in cancer: molecular basis of its occurrence. Current Opinion in Oncology, 14(1): 65-72.
- Thiagalingam, S., Sau, K., Cheng, K.H., Foy, R. L., and J.F. Ponte. (2000) Identification of upstream kinase regulators of p53 function. The FASEB Journal 14(8): 1331.
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