Nonhomologous end-joining of ionizing radiation induced DNA double stranded breaks in human tumor cells deficien




field gel electrophoresis: Calibration by means of 125I decay. Int. J. Radiat. Biol.  59, 343-357, 1991.
  • Metzger, L., and Iliakis, G.  Repair kinetics of DNA double strand breaks throughout the cell cycle measured by pulsed field gel electrophoresis.  Int. J. Radiat. Biol. 59, 1325-1339, 1991.
  • Iliakis, G.  The role of DNA double strand breaks in ionizing radiation induced killing of eucaryotic cells.  BioEssays.  13, 641-648, 1991.
  • Wang, Ya., and Iliakis, G.  Prolonged inhibition by x-rays of DNA synthesis in cells obtained by transformation of primary rat embryo fibroblasts with the oncogenes H-RAS and v-MYC.  Cancer Res.  52, 508-514, 1992.
  • Cheong, N., Wang, Y., Jackson, M., and Iliakis, G.  Radiation-sensitive IRS mutants rejoin DNA double strand breaks with efficiency similar to that of parental V-79 cells but show altered response to radiation induced G2-delay.  Mutat. Res. 274:111-122, 1992.
  • Muschel, R.J., Zhang, H.B., Iliakis, G., and McKenna, W.G.  Effects of ionizing radiation on cyclin expression in HeLa Cells.  Radiat. Res.  132:153-157, 1992.
  • Okayasu, R. and Iliakis, G.  Evidence that the product of the xrs gene is predominantly involved in the repair of a subset of radiation-induced interphase chromosome breaks rejoining with fast kinetics.  Radiat. Res. 138: 34-43, 1993.
  • Cheng, X., Pantelias, G.E., Okayasu, R., Cheong, N. and Iliakis, G.  MPF activity of inducer mitotic cells may affect the radiation yield of interphase chromosome breaks in the premature chromosome condensation assay.   Cancer Research,  53:5592-5596, 1993.
  • Okayasu, R., Varlotto, J., and Iliakis, G.  Hypertonic Treatment Does Not Affect The Radiation Yield Of Interphase Chromosome Breaks In DNA Double-Strand Break Repair Deficient xrs-5 Cells.  Radiat. Res. 135: 171-177, 1993.
  • Cheong, N., Wang, Y., and Iliakis, G., Radioresistance induced in rat embryo cells by transfection with the oncogenes H-ras and v-myc is cell cycle dependent and maximal during S and G2. Int. J Radiat. Biol. 63: 623-629, 1993.
  • Wang, Y., Cheong, N., and Iliakis, G.,  Persistent inhibition of DNA synthesis in irradiated rat embryo fibroblasts expressing the oncogenes H-ras plus v-myc derives from inhibition of replicon initiation and is mitigated by staurosporine.  Cancer Res. 53: 1213-1217, 1993.
  • Wang, X., and Iliakis, G.,  Persistent inhibition of DNA synthesis after radiation exposure in four clones obtained from rat embryo fibroblasts by transfection with the oncogenes H-ras plus v-myc. Int. J Radiat. Biol. 64: 165-168, 1993.
  • Cheong, N., Xiaoming, W., Wang, Y., and Iliakis, G.  Loss of S-Phase dependent radioresistance in irs-1 cells exposed to x-rays.  Mutat. Res. 314: 77-85, 1994.
  • Cheng, X. and Iliakis, G., Effect of ionizing radiation on the expression of chloramphenicol acetyltransferase gene under the control of commonly used constitutive or inducible promoters. Int. J. Radiat. Biol. 67: 261-267, 1995.
  • Wang, Y., Huq, M.S. Cheng, X., and Iliakis, G., Regulation of DNA replication in irradiated cells by trans-acting factors.    Radiat. Res.,  142: 169-175, 1995.
  • Ganguly, T. and Iliakis, G., A cell-free assay using cytoplasmic cell extracts to study rejoining of radiation-induced DNA double strand breaks in human cell nuclei. Int. J. Radiat. Biol. 68:447-457. 1995
  • Kinashi, Y., Okayasu, R., Iliakis, G.E., Nagasawa, H. and Little, J.B.,  Induction of DNA double strand breaks by restriction enzymes in x-ray sensitive mutant CHO cells (xrs-5) measured by pulse field gel electrophoresis.   Radiat. Res. 141:153-159, 1995.
  • Wang, Y., Huq, M.S. and Iliakis, G. Evidence for activities inhibiting in trans initiation of DNA replication in extract prepared from irradiated cells.  Radiat. Res. 145:408-418, 1996.
  • Cheong, N., Okayasu, R., Shah, S., Ganguly, T., Mammen, and Iliakis, G.  In vitro rejoining of double strand breaks in cellular DNA by factors present in extracts of HeLa cells. Int. J. Radiat. Biol. 69: 665-677, 1996.
  • Cheong, N., and Iliakis, G., In vitro rejoining of double strand breaks induced in cellular DNA by bleomycin and restriction endonucleases.  Int. J. Radiat. Biol. 71: 365-375, 1997.
  • Wang, Y., Perrault, R., and Iliakis, G.,  Down-Regulation of DNA Replication in Extracts of Camptothecin-Treated Cells: Activation of an S-phase Checkpoint? Cancer Res. 57: 1654-1659, 1997.
  • Iliakis, G.  Cell cycle regulation in irradiated and nonirradiated cells. Seminars in Oncology, 24: 602-615, 1997.
  • Wang, Y., Perrault, R., and Iliakis, G.,  Replication Protein A as a Potential Regulator of DNA Replication in Cells Exposed to Hyperthermia.  Radiation Res. 149: 284-293, 1997.
  • Cheong, N., Perrault, A.R., and Iliakis, G.  In vitro rejoining of double strand breaks: A comparison of genomic-DNA with plasmid-DNA based assays. Int. J. Radiat. Biol., 73:481-493, 1998.
  • Cheong, N., Perrault, R, Wang, H., Wachsberger, P., Mammen, P., Jackson, I. and Iliakis, G. DNA-PK-independent rejoining of DNA double strand breaks in human cell extracts in vitro. Int. J. Radiat. Biol. 75:67-81, 1999.
  • Iliakis, G. and Cheong, N.  In vitro rejoining of double strand breaks in genomic DNA.  Methods in Molecular Biology. DNA Repair Protocols: Eukaryotic Systems. Vol. 113: 473-486,1999.
  • Iliakis, G. Wang, Y. and Wang, H-Y. Analysis of inhibition of DNA replication in irradiated cells using the SV40 based in vitro assay of DNA replication.  Methods in Molecular Biology. DNA Repair Protocols: Eukaryotic Systems. Vol. 113:543-553, 1999.
  • Wachsberger, P.R., Li, W-H., Guo, M., Chen, D., Cheong, N., Ling, C.C., and Iliakis, G. Rejoining of DNA double strand breaks in Ku80-deficient mouse fibroblasts. Radiation Research, 151:398-407, 1999.
  • Wachsberger, P.R., and Iliakis, G. Hyperthermia does not affect rejoining of DNA double-strand breaks in a cell-free assay.  Int. J. Radiat. Biol.  76:313-326-2000.
  • Wang, Y., Zhou, X.Y., Wang, H-Y. Huq, S., and Iliakis, G. Roles of replication protein A and DNA-dependent protein kinase in the regulation of DNA replication following DNA damage. J Biol. Chem., 274:22060-22064, 1999.
  • DiBiase, S.J., Guan, J., Curran, Jr., W.J., and Iliakis, G.  Repair of DNA double-strand breaks and radiosensitivity to killing in an isogenic group of p53 mutant cell lines.  Int. J. Radiat. Oncol. Biol. Phys. 45:743-751, 1999.
  • DiBiase, S.J., Zeng, Z-C., Chen, R., Hyslop, T., Curran, W.J., and Iliakis, G. DNA-dependent protein kinase stimulates an independently active, non-homologous, end-joining apparatus. Cancer Research, 60:1245-1253, 2000.
  • Kurdoglu, B., Cheong, N., Guan, J., Corn, B.J., Curran, Jr., W.J., and Iliakis, G.  Apoptosis as a predictor of paclitaxel-induced radiosensitization in human tumor cell lines. Clinical Cancer Res., 5:2580-2587, 1999.
  • Guan, J. DiBiase, S. and Iliakis, G.  The catalytic subunit DNA-dependent protein kinase (DNA-PKcs) facilitates recovery from radiation-induced inhibition of DNA replication. Nucleic Acids Research, 28:1183-1192, 2000.
  • Asaad, N.A., Zeng, Z-C., Guan, J., Thacker, J. and Iliakis, G.  Homologous recombination as a potential target for caffeine radiosensitization in mammalian cells: reduced caffeine radiosensitization in XRCC2 and XRCC3 mutants.  Oncogene, 19:5788-5800, 2000.
  • Wang, H., Zeng, Z-C., Bui, T-A., Sonoda, E., Takata, M., Takeda, S., and Iliakis, G.  Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group.  Oncogene, In Press, 2001.
  • Wang, H-C.,  Zeng Z-C., Bui, T-A., DiBiase, S-.J., Qin. W.,  Xia, F., Powell, S.N., and Iliakis, G.  Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2.  Cancer Research, 61:270-277, 2001.
  • Perrault, R., Cheong, N., Wang, H., Wang, H., and Iliakis, G.  RPA facilitates rejoining of DNA double strand breaks in an in vitro assay utilizing genomic DNA as substrate.  Int. J. Radiat. Biol.  In Press, 2001.
  • Cheong, N., Zeng, Z-C., Wang, Y. and Iliakis, G.  Evidence for factors modulating radiation-induced G2-delay: Potential application as radioprotectors. In Press. Physica Medica, Vol. XVII, Supplement 1, 2001.
  • Wang, H.,  Zeng, Z-C., Perrault, A.R., Cheng,X., Qin, W., and Iliakis, G.  Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous endjoining in mammalian cells.  Nucleic Acids Research, 29: 1653-1660, 2001.
  • Wang, Y., Guan, J.,  Wang, H., Wang, Y., Leeper, D., and Iliakis, G.  Regulation Of DNA Replication After Heat Shock By RPA-Nucleolin Interactions. J. Biol. Chem. In Press, 276:000-000 2001.
  • Andrews, D.W., Resnicoff, M., Flanders, A.E., Kenyon, L., Curtis, M., Merli, G. Baserga, R., Iliakis, G., and Aiken, R.D.  Results of a pilot study involving the use of an antisense oligodeoxynucleotide directed against the insulin-like growth factor type I receptor in malignant astrocytomas.  J Clinical Oncology, 19: 2189-2200, 2001.
  • Hu, B., Zhou, X-Y., Wang, X., Zeng, Z-C., Iliakis, G., and Wang, Y.  The radioresistance to killing of A1-5 cells derives from activation of the Chk1 pathway. J. Biological Chemistry, 276: 000-000, 2001.
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      Nonhomologous end-joining of ionizing radiation induced DNA double stranded breaks in human tumor cells deficien

      field gel electrophoresis: Calibration by means of 125I decay. Int. J. Radiat. Biol.  59, 343-357, 1991.
    1. Metzger, L., and Iliakis, G.  Repair kinetics of DNA double strand breaks throughout the cell cycle measured by pulsed field gel electrophoresis.  Int. J. Radiat. Biol. 59, 1325-1339, 1991.
    2. Iliakis, G.  The role of DNA double strand breaks in ionizing radiation induced killing of eucaryotic cells.  BioEssays.  13, 641-648, 1991.
    3. Wang, Ya., and Iliakis, G.  Prolonged inhibition by x-rays of DNA synthesis in cells obtained by transformation of primary rat embryo fibroblasts with the oncogenes H-RAS and v-MYC.  Cancer Res.  52, 508-514, 1992.
    4. Cheong, N., Wang, Y., Jackson, M., and Iliakis, G.  Radiation-sensitive IRS mutants rejoin DNA double strand breaks with efficiency similar to that of parental V-79 cells but show altered response to radiation induced G2-delay.  Mutat. Res. 274:111-122, 1992.
    5. Muschel, R.J., Zhang, H.B., Iliakis, G., and McKenna, W.G.  Effects of ionizing radiation on cyclin expression in HeLa Cells.  Radiat. Res.  132:153-157, 1992.
    6. Okayasu, R. and Iliakis, G.  Evidence that the product of the xrs gene is predominantly involved in the repair of a subset of radiation-induced interphase chromosome breaks rejoining with fast kinetics.  Radiat. Res. 138: 34-43, 1993.
    7. Cheng, X., Pantelias, G.E., Okayasu, R., Cheong, N. and Iliakis, G.  MPF activity of inducer mitotic cells may affect the radiation yield of interphase chromosome breaks in the premature chromosome condensation assay.   Cancer Research,  53:5592-5596, 1993.
    8. Okayasu, R., Varlotto, J., and Iliakis, G.  Hypertonic Treatment Does Not Affect The Radiation Yield Of Interphase Chromosome Breaks In DNA Double-Strand Break Repair Deficient xrs-5 Cells.  Radiat. Res. 135: 171-177, 1993.
    9. Cheong, N., Wang, Y., and Iliakis, G., Radioresistance induced in rat embryo cells by transfection with the oncogenes H-ras and v-myc is cell cycle dependent and maximal during S and G2. Int. J Radiat. Biol. 63: 623-629, 1993.
    10. Wang, Y., Cheong, N., and Iliakis, G.,  Persistent inhibition of DNA synthesis in irradiated rat embryo fibroblasts expressing the oncogenes H-ras plus v-myc derives from inhibition of replicon initiation and is mitigated by staurosporine.  Cancer Res. 53: 1213-1217, 1993.
    11. Wang, X., and Iliakis, G.,  Persistent inhibition of DNA synthesis after radiation exposure in four clones obtained from rat embryo fibroblasts by transfection with the oncogenes H-ras plus v-myc. Int. J Radiat. Biol. 64: 165-168, 1993.
    12. Cheong, N., Xiaoming, W., Wang, Y., and Iliakis, G.  Loss of S-Phase dependent radioresistance in irs-1 cells exposed to x-rays.  Mutat. Res. 314: 77-85, 1994.
    13. Cheng, X. and Iliakis, G., Effect of ionizing radiation on the expression of chloramphenicol acetyltransferase gene under the control of commonly used constitutive or inducible promoters. Int. J. Radiat. Biol. 67: 261-267, 1995.
    14. Wang, Y., Huq, M.S. Cheng, X., and Iliakis, G., Regulation of DNA replication in irradiated cells by trans-acting factors.    Radiat. Res.,  142: 169-175, 1995.
    15. Ganguly, T. and Iliakis, G., A cell-free assay using cytoplasmic cell extracts to study rejoining of radiation-induced DNA double strand breaks in human cell nuclei. Int. J. Radiat. Biol. 68:447-457. 1995
    16. Kinashi, Y., Okayasu, R., Iliakis, G.E., Nagasawa, H. and Little, J.B.,  Induction of DNA double strand breaks by restriction enzymes in x-ray sensitive mutant CHO cells (xrs-5) measured by pulse field gel electrophoresis.   Radiat. Res. 141:153-159, 1995.
    17. Wang, Y., Huq, M.S. and Iliakis, G. Evidence for activities inhibiting in trans initiation of DNA replication in extract prepared from irradiated cells.  Radiat. Res. 145:408-418, 1996.
    18. Cheong, N., Okayasu, R., Shah, S., Ganguly, T., Mammen, and Iliakis, G.  In vitro rejoining of double strand breaks in cellular DNA by factors present in extracts of HeLa cells. Int. J. Radiat. Biol. 69: 665-677, 1996.
    19. Cheong, N., and Iliakis, G., In vitro rejoining of double strand breaks induced in cellular DNA by bleomycin and restriction endonucleases.  Int. J. Radiat. Biol. 71: 365-375, 1997.
    20. Wang, Y., Perrault, R., and Iliakis, G.,  Down-Regulation of DNA Replication in Extracts of Camptothecin-Treated Cells: Activation of an S-phase Checkpoint? Cancer Res. 57: 1654-1659, 1997.
    21. Iliakis, G.  Cell cycle regulation in irradiated and nonirradiated cells. Seminars in Oncology, 24: 602-615, 1997.
    22. Wang, Y., Perrault, R., and Iliakis, G.,  Replication Protein A as a Potential Regulator of DNA Replication in Cells Exposed to Hyperthermia.  Radiation Res. 149: 284-293, 1997.
    23. Cheong, N., Perrault, A.R., and Iliakis, G.  In vitro rejoining of double strand breaks: A comparison of genomic-DNA with plasmid-DNA based assays. Int. J. Radiat. Biol., 73:481-493, 1998.
    24. Cheong, N., Perrault, R, Wang, H., Wachsberger, P., Mammen, P., Jackson, I. and Iliakis, G. DNA-PK-independent rejoining of DNA double strand breaks in human cell extracts in vitro. Int. J. Radiat. Biol. 75:67-81, 1999.
    25. Iliakis, G. and Cheong, N.  In vitro rejoining of double strand breaks in genomic DNA.  Methods in Molecular Biology. DNA Repair Protocols: Eukaryotic Systems. Vol. 113: 473-486,1999.
    26. Iliakis, G. Wang, Y. and Wang, H-Y. Analysis of inhibition of DNA replication in irradiated cells using the SV40 based in vitro assay of DNA replication.  Methods in Molecular Biology. DNA Repair Protocols: Eukaryotic Systems. Vol. 113:543-553, 1999.
    27. Wachsberger, P.R., Li, W-H., Guo, M., Chen, D., Cheong, N., Ling, C.C., and Iliakis, G. Rejoining of DNA double strand breaks in Ku80-deficient mouse fibroblasts. Radiation Research, 151:398-407, 1999.
    28. Wachsberger, P.R., and Iliakis, G. Hyperthermia does not affect rejoining of DNA double-strand breaks in a cell-free assay.  Int. J. Radiat. Biol.  76:313-326-2000.
    29. Wang, Y., Zhou, X.Y., Wang, H-Y. Huq, S., and Iliakis, G. Roles of replication protein A and DNA-dependent protein kinase in the regulation of DNA replication following DNA damage. J Biol. Chem., 274:22060-22064, 1999.
    30. DiBiase, S.J., Guan, J., Curran, Jr., W.J., and Iliakis, G.  Repair of DNA double-strand breaks and radiosensitivity to killing in an isogenic group of p53 mutant cell lines.  Int. J. Radiat. Oncol. Biol. Phys. 45:743-751, 1999.
    31. DiBiase, S.J., Zeng, Z-C., Chen, R., Hyslop, T., Curran, W.J., and Iliakis, G. DNA-dependent protein kinase stimulates an independently active, non-homologous, end-joining apparatus. Cancer Research, 60:1245-1253, 2000.
    32. Kurdoglu, B., Cheong, N., Guan, J., Corn, B.J., Curran, Jr., W.J., and Iliakis, G.  Apoptosis as a predictor of paclitaxel-induced radiosensitization in human tumor cell lines. Clinical Cancer Res., 5:2580-2587, 1999.
    33. Guan, J. DiBiase, S. and Iliakis, G.  The catalytic subunit DNA-dependent protein kinase (DNA-PKcs) facilitates recovery from radiation-induced inhibition of DNA replication. Nucleic Acids Research, 28:1183-1192, 2000.
    34. Asaad, N.A., Zeng, Z-C., Guan, J., Thacker, J. and Iliakis, G.  Homologous recombination as a potential target for caffeine radiosensitization in mammalian cells: reduced caffeine radiosensitization in XRCC2 and XRCC3 mutants.  Oncogene, 19:5788-5800, 2000.
    35. Wang, H., Zeng, Z-C., Bui, T-A., Sonoda, E., Takata, M., Takeda, S., and Iliakis, G.  Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group.  Oncogene, In Press, 2001.
    36. Wang, H-C.,  Zeng Z-C., Bui, T-A., DiBiase, S-.J., Qin. W.,  Xia, F., Powell, S.N., and Iliakis, G.  Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2.  Cancer Research, 61:270-277, 2001.
    37. Perrault, R., Cheong, N., Wang, H., Wang, H., and Iliakis, G.  RPA facilitates rejoining of DNA double strand breaks in an in vitro assay utilizing genomic DNA as substrate.  Int. J. Radiat. Biol.  In Press, 2001.
    38. Cheong, N., Zeng, Z-C., Wang, Y. and Iliakis, G.  Evidence for factors modulating radiation-induced G2-delay: Potential application as radioprotectors. In Press. Physica Medica, Vol. XVII, Supplement 1, 2001.
    39. Wang, H.,  Zeng, Z-C., Perrault, A.R., Cheng,X., Qin, W., and Iliakis, G.  Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous endjoining in mammalian cells.  Nucleic Acids Research, 29: 1653-1660, 2001.
    40. Wang, Y., Guan, J.,  Wang, H., Wang, Y., Leeper, D., and Iliakis, G.  Regulation Of DNA Replication After Heat Shock By RPA-Nucleolin Interactions. J. Biol. Chem. In Press, 276:000-000 2001.
    41. Andrews, D.W., Resnicoff, M., Flanders, A.E., Kenyon, L., Curtis, M., Merli, G. Baserga, R., Iliakis, G., and Aiken, R.D.  Results of a pilot study involving the use of an antisense oligodeoxynucleotide directed against the insulin-like growth factor type I receptor in malignant astrocytomas.  J Clinical Oncology, 19: 2189-2200, 2001.
    42. Hu, B., Zhou, X-Y., Wang, X., Zeng, Z-C., Iliakis, G., and Wang, Y.  The radioresistance to killing of A1-5 cells derives from activation of the Chk1 pathway. J. Biological Chemistry, 276: 000-000, 2001.
      		43.
      PrePage12
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