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1959年4月～1961年3月    东京大学理学部生物化学专业硕士

1961年4月              东京大学理学部生物化学专业博士入学

1965年6月              东京大学理学部生物化学专业博士中途退学 
 
 

1965年7月              爱知县癌症研究中心生物科研究员

1970年4月              爱知县癌症研究中心生物科主任研究员

1970年11月～1971年10月  美国芝加哥大学留学　　

1985年4月              爱知县癌症研究中心病态学科主任研究员

1993年3月              爱知县癌症研究中心辞职

1993年4月              东京工业大学生命理工系生物分子学科研究员

1998年3月              东京工业大学生命理工系生物分子学科辞职

1998年4月              财团法人日本皮革研究所研究员

2003年3月              财团法人日本皮革研究所辞职

1995年4月～2003年4月　  川崎市立看护短期大学讲师

2003年4月-              沈阳药科大学副教授

1. 虽然人们已经清楚肿瘤是由基因突变所引起的，但是目前采用基因治疗仍然很困难。为了防治癌症患者的死亡，本实验室致力于肿瘤转移机制的研究，尤其是对神经节苷脂抑制肿瘤转移性的细胞信号转导通路的研究，希望能够发现抑制肿瘤转移的药物。
2. 2，细胞表面的糖链与细胞的识别，粘附，移动，分裂有着密切的关系，为了研究糖链的机能，本实验室致力于利用细胞合成各种糖链的研究。我们认为如果能清楚糖链调控细胞功能的机理，不仅能够解释一些疾病的病因，而且还能开发出相应的治疗药物。

        Ganglioside GD1a inhibits the HGF/SF-induced motility and scattering of cancer cells through suppression of tyrosine-phosphorylation of c-Met.

        Int. J. Cancer, 94, 328-334 (2001)　PMID: 11745410

Kasuya, M. C. Z., Wang, L. X., Lee, Y. C, Mitsuki, M., Nakajima, H.,Miura, Y., Sato, T., Hatanaka, K., Yamagata, S., and Yamagata, T.

        Azido glycoside primer: A versatile building block for the biocombinatorial synthesis of glycosphingolipid analogues.

        Carbohydr. Res. 329, 755-763 (2000)　PMID: 11125817

Hyuga,S., Kawasaki, N., Hashimoto, O., Hyuga, M., Ohta, M., Yamagata, S., Yamagata, T., and Hayakawa, T.

        Possible role of hepatosyte growth factor/scatter factor and activin A produced by the target organ in liver metastasis

        Cancer Lett., 153, 137-143 (2000)　PMID: 10779642

Hyuga, S., Yamagata, S., Takatsu, Y., Hyuga, M., Nakanishi, H., Furukawa, K. and Yamagata, T.

        Suppression of FBJ-LL cell adhesion to vitronectin by ganglioside GD1a and loss of metastatic capacity.

        Int. J. Cancer, 83, 685-691 (1999)　PMID: 10521808

Nagaya, N., Yamagata, T., Yamagata, S., Iyoda, K., Ito, H., Hasegawa, Y., and Iwata, H.,

        Examination of synovial fluid and serum hyaluronidase activity as a joint marker in rheumatoid arthritis and osteoarthritis patients (by zymography)

        Ann. Rheum. Dis., 58, 186-188 (1999)

Podyma, K.A., Yamagata, S., Sakata, K., and Yamagata, T.

        Difference of hyaluronidase produced by human tumor cell lines with hyaluronidase present in human serum.as revealed by zymography

        Biochem. Biophys. Res. Commun., 241, 446-450 (1997)　PMID: 9425290

Tamakoshi, K., Kikkawa, F., Yamagata, S., Yamagata, T., and Tomoda, Y.

        Hyaluronidase activity in gynecologic cancer tissue with different metastatic forms.

        British J. Cancer, 75, 1807-1811 (1997)　PMID: 9192986

Kikkawa, F., Tamakoshi, K., Nawa, A., Shibata, K., Yamagata, S., Yamagata, T., and Suganuma, N.

        Positive correlation between inhibitors of matrix metalloproteinase 1 and matrix metalloproteinases in malignant ovarian tumor tissues.

        Cancer Lett., 120, 109-115 (1997)　PMID: 9570393

Hyuga, S., Yamagata, S., Tai, T., and Yamagata, T.

        Inhibition of highly metastatic FBJ-LL cell migration by ganglioside GD1a highly expressed in poorly metastatic FBJ-S1 cells.

        Biochem. Biophys. Res. Commun., 231, 340-343 (1997)　PMID: 9070274

Miura, R.O., Yamagata, S., Harada, T., Miura, Y., and Yamagata, T.

        Analysis of glycosaminoglycan degrading enzymes by substrate gel electrophoresis (Zymography).

        Anal. Biochem., 225, 333-340  (1995)　PMID: 7762800

Sakata, K., Kozaki, K., Iida, K., Tanaka, R., Yamagata, S., Utsumi, KR., Saga, S., Shimizu, S., and Matsuyama, M.

        Establishment and characterization of high and low-lung-metastatic cell lines delived from murine colon adenocarcinoma 26 tumor line.

        Jpn. J. Cancer Res., 87, 78-85 (1996)　PMID: 8609053

Tamakoshi, K., Kikkawa, F., Nawa, A., Ishikawa, H., Mizuno, K., Tamakoshi, A., Ya,magata, S.,  Suganuma, N., and Tomoda, Y.

Characterization of extracellular matrix-degrading proteinase and its inhibitor in gynecologic cancer tissues with clinically different metastatic form.

        Cancer, 76, 2565-2571 (1995)　PMID: 8625086

Hamaguchi, M., Yamagata, S., Thant, AA., Xiao, H., Iwata, H., Mazaki, T., and Hanafusa, H.

        Augmentation of metalloproteinase(gelatinase) activity secreted from Rous sarcoma virus-infected cells correlates with transforming activity of src.

        Oncogene, 10, 1037-1043 (1995)

Tamakoshi, K., Kikkawa, F., Nawa, A., Maeda, O., Kawai, M., Sugamura, N., Yamagata, S., and Tomoda, Y.

        Different pattern of zymography between human gynecologic normal and malignant tissues.

        Am. J. Obstet Gynecol., 171, 478-484 (1994)　PMID: 8059829

Hyuga, S., Nishikawa, Y., Sakata, K., Tanaka, H., Yamagata, S., Sugita, K., Saga, S., Matuyama, M., and Shimizu, S.

        Autocrine factor enhancing the secretion of M(r)95,000 gelatinase(matrix metalloproteinase 9) in serum-free medium conditioned with murine metastatic colon carcinoma cells.

        Cancer Res., 54, 3611-3616 (1994)　PMID: 8012988

Kishi, J., Tanaka, R., Koiwai, O., Yamagata, S., Numata, Y., Hayakawa, T., and Shimizu, S.

        Gelatinases and metalloproteinase inhibitor secreted by murine colonic carcinoma cells with differing metastaitic potential.

        Cell Biol. Int., 18, 165-170 (1994)　PMID: 8019490

Nakanishi, H., Yasui, K., Yamagara, S., Shimizu, S., Ando, S., and Hosoda, S.

        Establishment and characterization of a new spontaneous metastasis model of human gastric carcinoma in nude mice.

        Jpn. J. Cancer Res., 82,  927-933 (1991)　PMID: 1654313

Yamagata, S., Yoshii, Y., Suh, JG, Tanaka, R., and Shimizu, S.

        Occurrence of an active form of gelatinase in human gastric and colorectal cqrcinoma tissues.

        Cancer Lett., 59, 51-55 (1991)　PMID: 1652352

Higashi, H., Ito, M., Fukaya, N., Yamagata, S., and Yamagata, T.

        Two-dimensional mapping by the high-performance liquid chromatography of oligosaccharides released from glycosphingolipids by endoglycoceramidase.

        Anal. Biochem., 186, 355-362 (1990)　PMID: 2363510

Yamagata, S., Tanaka, R., Ito, Y., and Shimizu S.

        Gelatinase of murine metastatic tumor cells.

        Biochem. Biophys. Res. Commun., 158, 228-234 (1989)　PMID: 2536277

Yamagata, S., Ito, Y., Tanaka, R., and Shimizu S.

        Gelatinase of metastatic cell lines of murine colonic carcinaoma as detected by substrate-gel eledtrophoresis.

        Biochem. Biophys. Res. Commun., 151, 158-162 (1988)　PMID: 2831877

Hashimoto, Y., Yamagata, S., and Hayakawa, T.

        Amino acid analysis by high-performance liquid chromatography of a single stained band from a polyacrylamide gel.

        Anal. Biochem.,  160, 362-367, (1987)　PMID: 3578764

Yamagata, S., and Yamagata, Y.,

        The staining of type V collagen obtained from FBJ virus-induced osteosarcoma with concanavalin A.

        Biochem. Biophy. Res. Commun., 136, 857-862 (1986)　PMID: 3459458

Yamagata, S., and Yamagata, T.

        FBJ Virus-induced osteosarcoma contains type I, type I trimer, type III as well as type V collagens.

        J. Biochem., 96, 17-26 (1984)　PMID: 6593319

Yamagata, S., Miwa, M., Tanaka, K., and Yamagata, T.

        FBJ virus-induced osteosarcoma has type V collagen consisting of A, B and C-like chains in addition to type I collagen.

        Biochem. Biophys. Res. Comm., 105, 1208-1214 (1982)　PMID: 6284167.

Yasumoto, S., Kato, Y., Oguri, K., Yamagata, S., and Yamagata, T　

        Maintenance of phenotypic properties by chondrocytes cultured in suspension.

        Develop. Growth and Differ., 22, 445-459 (1980)

Kawabe, N., and Yamagata, S.

        Mucopolysaccharides anad proteoglycans of chondrosarcoma.

        Connective Tissue, 11, 91-105 (1979)

Baker J.R., Roden, L., and Yamagata, S.

        Smith-degraded cartilage proteoglycan as an acceptor for xylosyl transfer.

        Biochem. J., 125, 93(1971)　PMID: 4259341

Yamagata, S., Takahashi, K., and Egami, F.

        The structure and function of Ribonuclease T1 VI.

        J. Biochem., 52, 272 (1962)　PMID: 14002268

Yamagata, S., Takahashi, K., and Egami, F.

        The structure and function of Ribonuclease T1 IV.　PMID: 14002267

        J. Biochem., 52, 261 (1962)