Publications

1. Jen, J., Deschepper, C.F., Shackleford, G.M., Lee, C-Y.G., and Lau, Y-F.C. Stage-specific expression of the lactate dehydrogenase-X gene in adult and developing mouse testes.Molecular Reproduction and Development 25:14-21, 1990.
2. Mitchell, D.L., Jen, J., and Cleaver, J.E. Relative induction of cyclobutane dimers and cytosine photohydrates in DNA irradiated in vitro and in vivo with ultraviolet-C and ultraviolet-B light.  Photochemistry and Photobiology 54:741-746, 1991.
3. Mitchell, D.L., Jen, J., and Cleaver, J.E. Sequence specificity of cyclobutane pyrimidine dimers in DNA treated with solar (ultraviolet B) radiation.  Nucleic Acid Research  20:225-229, 1992.
4. Powell, S.M., Petersen, G.M., Krush, A.J., Booker, S., Jen, J., Giardiello, F.M., Hamilton,S.R., Vogelstein, B., and Kinzler, K.W.  Molecular diagnosis of familial adenomatous polyposis.  New England Journal of Medicine 329: 1982-1987, 1993.
5. Parsons, R., Li, G-M., Longley, M.J., Fang, W-H., Papadopoulos, N., Jen, J., de la Chapelle, A., Kinzler, K.W., Vogelstein B., and Modrich, P.  Hypermutability and Mismatch Repair Deficiency in RER+ Tumor Cells.  Cell 75: 1227-1236, 1993.
6. Leach, F.S., Nicolaides, N.C., Papadopoulos, N., Liu, B., Jen, J., Parsons, R., et al., Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer.  Cell 75: 1215-1225, 1993.
7. Kim, H., Jen, J., Vogelstein, B., and Hamilton, S.R.  Clinical and Pathological Characteristics of Sporadic Colorectal Carcinomas with DNA Replication Errors in Microsatellite Sequences. American Journal of Pathology 145: 148-156, 1994.
8. Jen, J., Powell, S.M., Papadopoulos, N., Smith, K.J., Hamilton, S.R., Vogelstein, B., and Kinzler, K.W.  Molecular Determinants of Dysplasia in Colorectal Lesions. Cancer Research 54: 5523-5526, 1994.
9. Jen, J., Kim, H., Piantadosi, S., Liu, Z-F., Levitt, R.C., Sistonen, P., Kinzler, K.W., Vogelstein, B., and Hamilton, S.R.  Allelic loss of chromosome 18q and prognosis in colorectal cancer.  New England Journal of Medicine 331: 213-221, 1994.
10. Jen, J., Harper, J.W., Bigner, S.H., Bigner, D.D., Papadopoulos, N., Markowitz, S., Willson, J.K.V., Kinzler, K.W., and Vogelstein, B.  Deletion of p16 and p15 Genes in Brain Tumors. Cancer Research 54: 6353-6358, 1994.
11. Liu, B., Nicolaides, N.C., Markowitz, S., Willson, J.K.V., Parsons, R.E., Jen, J., Papadopolous, N., Peltomaki, P., de la Chapelle, A., Hamilton, S.R., Kinzler, K.W., and Vogelstein, B.  Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability.  Nature Genetics 9:48-55, 1995.
12. Herman J.G., Jen, J., Merlo, A., and Baylin, S.B. Hypermethylation-associated inactivation indicates a tumor suppressor role for p15^INK4B1.  Cancer Research 56,722-727, 1996.
13. Da Costa, L., Jen J., He, T.C., Kinzler, K.W., and Vogelstein, B. Converting cancer genes into killer genes.Procedings of the National Academy of Sciences. 93:4192-4196, 1996
14. Jen, J., Mitchell, D.L., Cunningham, R.P., Smith, C.A., Taylor, J.S. and Cleaver, J.E. Ultraviolet irradiation produces a novel endonuclease III-sensitive cytosine photoproducts at dipyrimidine sites. Photochem Photobio 65(2):323-329, 1997.
15. Okami, K., Cairin P, Westra, W., Linn J, Ahrent, SA., Wu, L, Sidransky, D, and Jen, J Detailed deletion mapping at chromosome 9p21 in Non-small cell lung cancer by microsatellite analysis and fluorescence in situ hybridization. International Journal of Cancer 74,1-5 (1997).
16. Okami, K., Wu, L., Riggins, G., Cairns, P., Goggins, M., Evron, E., Halachmi, N., Ahrendt, S., Reed, A., Hilgers, W., Kern, S., Sidransky, D. and Jen, J. Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors. Cancer Research. 58:509-511, 1998.
17. Hibi., K., Robinson, R., Booker, S., Wu, L., Hamilton, S.R., Sidransky, D., and Jen, J. Molecular detection of genetic alterations in the serum of colorectal cancer patients. Cancer Research. 58:1405-1407, 1998.
18. Leong, P., Banafsheh, R., Reed, A., Koch, W., Lee, D., Sidransky, D., Jen, J., Westra, W.H. Distinguishing second primary tumors from metastases in patients with head and neck squamous cell carcinoma. Journal of National Cancer Institute. 90, 972-7(1998).
19. Trink, b., Okami, K., Wu, L., Sriuranpong, V., Jen, J., and Sidransky, D. A new human p53 homologue. Nature medicine. 4,3-4 (1998).
20. Hibi, K., Liu, Q., Westra, W., Wehage, S., Borges, M., Yang, S., Heitmiller, R., Sidransky, D., Jen, J. Serial analysis of genes overexpressed in non-small cell lung cancer. Cancer Research 58,5690-94 (1998).
21. Jen, J., Johnson, C. and Levin, B. Molecular approaches for colorectal cancer screening. European Journal of Gastroenterology and Hepatology. 10, 213-217,1998.
22. Ahrendt, S.A., Halachmi, S., Chow, J.T., Wu, L., Halachmi, N., Wehage, S., Jen, J., Sidransky, D. Rapid p53 sequence analysis using an oligonucleotide probe array in primary lung cancer. Proc Natl Acad Sci 96:7382-7 (1999).
23. Sanchez-Cespedes M, Reed AL, Buta M, Wu L, Westra WH, Herman JG, Yang SC, Jen J, Sidransky D. Inactivation of the INK4A/ARF locus frequently coexists with TP53 mutations in non-small cell lung cancer.  Oncogene 18(43):5843-9(1999).
24. Hibi K, Westra WH, Borges M, Goodman S, Sidransky D, Jen J. PGP9.5 as a candidate tumor marker for non-small-cell lung cancer. Am J Pathol 155:711-5 (1999)
25. Yamaguchi, K., Wu, L., Hibi, K., Trink, B., Cairns, P., Okami, K., Sidransky, D., and Jen, J. Frequent gain of the p40/p51/p63 gene locus in primary HNSCC. Int. J. Cancer 86(5):684-9 (2000).
26. Ahrendt, S.A., Decker, A.D., Doffek, K., Wang, B., Xu, L.H., Demeure, M.J., Jen, J., and Sidransky, D. Microsatellite instability at selected tetranucleotide repeats is associated with p53 mutations in non-small cell lung cancer. Cancer Res. 60(9):2488-91 (2000).
27. Makiko, S.F., Usadel, H., Caballero, O.L., Wu, L., Buta, M., Westra, W., Eleff, S., Jen, J., and Sidransky D. Facile detection of humoplasmic mitochondrial DNA mutations in primary tumors and bodily fluids. Science 287:2017-9 (2000).
28. Jen, J.  Microsatellite analysis to assess chromosome 18q status in colorectal cancer.  Methods in Molecular Medicine Powell, S (Ed) Humanna Press (2000)
29. Xu, L-H, Chow, J., Eisenberger, C., Bonacum, J., Ahrendt, S., Reed, A., Spafford, M., Westra, W.H, Yang, S., Sheng M. L, Piantadosi, S., Tockman, M., Sidransky, D., Jen, J., Microsatellite Instability at (AAAG) Repeat Sequences in Upper Aerodigestive Tract Cancers Int J Cancer 91(2):200-5 (2001)
30. Sanchez-Cespedes M, Ahrendt SA, Piantadosi, S., Rosell R., Monzo, M., Wu., Li., Westra, WH., Yang, SC., Jen, J., and Sidransky, D. Chromosomal alterations in lung adenoma from smokers and nonsmokers. Cancer Res 61(4):1309-13 (2001)
31. Rosas SL, Koch W, da Costa Carvalho MG, Wu L, Califano J, Westra W, Jen J, Sidransky D. Promoter hypermethylation patterns of p16, O6-methylguanine-DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients. Cancer Res 61(3):939-42 (2001)
32. Caballero, OL., Cohen, d., Liu Q., Esteller, M., Bonacum, J., White, P., Yochem, R., Herman, J., Westra, WH., Lengauer, C., Sidransky, D., and Jen J.  Loss of chromosome 3p, 9p, and inactivation of p16INK4a in normal epithelium of patients with primary lung cancer. Genes Chromosomes and Cancer 32(2):119-25 (2001)
33. Dong, SM., Traverso, G., Johnson, C., Geng, L., Favis, R., Boynton, K., Hibi, K., goodman, S., D’Allessio, M., Paty, P., Hamilton, S., Sidransky, D., Barany, F., Levin, B., Shuber, A., Kinzler, KW., Vogelstein, B., and Jen, J.  Detecting colorectal cancer in stool using multiple genetic targets. Journal of National Cancer Institute 93(11):798-9 (2001).
34. Rosas, S.L.B., Caballero, O.L., Carvalho, M.G.C., Sidransky, D., Jen, J.  Methylation Status in the Promoter Region of the Human PGP9.5 Gene in Cancer and Normal Tissue. Cancer Letters. 170(1):73-9 (2001)
35. Nacht M, Dracheva T, Gao YH, Fujii T, Chen YD, Player A, Akmaev V, Cook B, Dufault M, Zhang M, Zhang M, Guo MZ, Curran J, Han S, Sidransky D, Betow K, Madden SL, and Jen J. Molecular Characteristics of Non-Small Cell Lung Cancer. Proc. Nat. Acad. Science (In press, 2001)
36. Caballero, OL. Resto, V., Patturajan, M., Guo, MZ., Engles, J., Yochem, R., Ratoviski, E., Matunis, M., Sidransky, D., and Jen J.  Interaction and colocalization of PGP9.5 with JAB1 and P27^kip1. Oncogene. Submitted. 2001.